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Pfizer buys cancer drug biotech for $43B 

Published Wed, 27 Nov 2024 12:30:15 GMT

Pfizer is spending about $43 billion to reach deeper into new cancer treatments that target tumor cells while sparing surrounding healthy tissue.The pharmaceutical giant said Monday it will pay $229 in cash for each share of Seagen Inc. Pfizer then plans to let the biotech drug developer “continue innovating,” except with more resources than it would have alone, Pfizer Chairman and CEO Albert Bourla told analysts.“We are not buying the golden eggs,” he said. “We are acquiring the goose that is laying the golden eggs.”Seagen Inc., based in Bothell, Washington, specializes in working with antibody-drug conjugate, or ADC, technology. Its key products use lab-made proteins called monoclonal antibodies that seek out cancer cells to help deliver a cancer-killing drug while sparing surrounding tissue.Cancer treatments are a priority for Pfizer. They brought in $12 billion in revenue for the drugmaker last year. But Pfizer has only marketed a couple first...

NCAA Tournament Predictions: 4. UConn vs. 13. Iona

Published Wed, 27 Nov 2024 12:30:15 GMT

4. UConn (25-8, 13-7/Big East)- On their best day, the Huskies can play with anyone in the nation, as they proved during an undefeated non-conference run that saw them start out 14-0 and knock off Alabama en route to a Phil Knight Invitational title. UConn rose to as high as No. 2 in the country, but then came crashing back down to Earth immediately after, losing five of six to start the new year. UConn has since regained its confidence, and enters the Big Dance winners of 9 of its last 11 games.The Huskies can beat you in a number of ways, especially if projected first-round NBA Draft pick and instant-offense creator Jordan Hawkins (16.1 ppg, 36.8% 3-pt) gets going. UConn has several shooters ( Alex Karaban, Joey Calcaterra) who can get hot from deep and beat you, and all of that surrounds powerful big man and leading scorer Adama Sanogo in the paint (16.8 ppg, 7.3 rpg). Andre Jackson is a defensive force and pre...

NCAA Tournament Predictions: 4. Indiana vs. 13. Kent State

Published Wed, 27 Nov 2024 12:30:15 GMT

Indiana (22-11, 12-8/Big Ten)- Led by big man Trayce Jackson-Davis, Indiana was the Big Ten preseason favorite. And although the Hoosiers did not capture a Big Ten championship, they appear to be peaking at the right time and will be a dangerous team in the Midwest region.Jackson-Davis has been once again, spectacular (20.8 ppg, 57% FG) and is capable of taking over any game. Meanwhile, Indiana has developed a legit sidekick in 6-foot-6 freshman Jalen Hood-Schifino (13.5 ppg, 4.1 rpg, 3.7 apg) who has excellent shot-making abilities and could be a lottery pick if he leaves for the NBA after this season.However, the Hoosiers (77th in defensive rating) have been vulnerable defensively this season at times and have also been victim to a few true clunkers, with a 22-point home loss to Iowa and 19-point road defeat at Penn State the most egregious.Indiana hasn’t been to a Sweet 16 since 2016, a sting on a proud program. Mike Woodson has done well to ge...

WATCH: President Biden delivers remarks in San Diego on submarine deal

Published Wed, 27 Nov 2024 12:30:15 GMT

SAN DIEGO -- President Joe Biden landed in San Diego shortly after noon Monday for a meeting with the British and Australian Prime Ministers to discuss the countries' partnership and defense issues, as China's military influence has become a growing concern for world leaders.The leaders announced a historic deal in a joint press conference with the leaders that would modernize Australia's naval fleet by equipping the country with nuclear-powered attack submarines through AUKUS, a trilateral security pact formed between the three countries in 2021 to develop submarine capabilities in the Indo-Pacific region.As part of the plan unveiled by the White House Monday, the three countries will roll out a phased approach to introduce these submarines -- used for their capabilities to travel underwater for longer without needing to surface -- to the Australian military. US, UK try to halt fallout from Silicon Valley Bank collapse By the early 2030s, up to five Virginia-class submarines will...

Vehicle crashed into store in Dundas Street West and Windermere Avenue area

Published Wed, 27 Nov 2024 12:30:15 GMT

A vehicle has crashed into a store in the Dundas Street West and Windermere Avenue area on Monday afternoon.COLLISION:Dundas St W & Windermere Ave 4:14pm– reports of vehicle driving into store– police are o/s– no injuries – possible delays in the area– consider alternate routes#GO566435^se— Toronto Police Operations (@TPSOperations) March 13, 2023Police responded to reports at approximately 4:14 p.m. of a vehicle driving into a store.No one was injured in the incident, though no further details about the crash have been released and there are possible delays in the area.

S&P/TSX composite down almost one per cent, U.S. markets mixed over bank failures

Published Wed, 27 Nov 2024 12:30:15 GMT

TORONTO — Worries about the financial system after two recent bank failures saw bank stocks edge U.S. markets mostly down Monday after a volatile day of trading while Canadian markets fell on weakness in energy and financials. The S&P/TSX composite index was down 186.02 points at 19,588.90.In New York, the Dow Jones industrial average was down 90.50 points at 31,819.14. The S&P 500 index was down 5.83 points at 3,855.76, while the Nasdaq composite was up 49.96 points at 11,188.84.The Canadian dollar traded for 72.83 cents US compared with 72.43 cents US on Friday.The April crude contract was down US$1.88 at US$74.80 per barreland the April natural gas contract was up 18 cents at US$2.61 per mmBTU.The April gold contract was up US$49.30 at US$1,916.50 an ounceand the May copper contract was up two cents at US$4.05 a pound.This report by The Canadian Press was first published March 13, 2023.Companies in this story: (TSX:GSPTSE, TSX:CADUSD=X)The Canadian Press

Whitby restaurant owner charged in sex assaults dating back to 2005

Published Wed, 27 Nov 2024 12:30:15 GMT

A Whitby restaurant owner who was previously charged in a workplace sexual assault investigation is now facing more than half-a-dozen additional charges after police say more alleged victims came forward.Durham Regional Police originally charged James Chatterpaul in January 2023 after a person came forward claiming they were sexually assaulted by him at his restaurant. Chatterpaul is the owner of Chatterpaul’s restaurant at 3500 Brock Street in Whitby.Since then, investigators say four more alleged victims have come forward, claiming they were sexually assaulted by Chatterpaul between 2005 and 2019.Police say Chatterpaul often goes by the names “Chef Chad” or “Chad” and note that he was previously employed at an Oshawa restaurant.Chatterpaul, 55, of Whitby, is facing seven additional counts of sexual assault.

Divided jury means no death penalty for NYC bike path killer

Published Wed, 27 Nov 2024 12:30:15 GMT

NEW YORK (AP) — A split among jurors means there will be no death penalty for an Islamic extremist who maniacally raced a truck along a popular New York City bike path, killing eight people and maiming others.The decision means Sayfullo Saipov, 35, an Uzbekistan citizen who lived in New Jersey, gets an automatic sentence of life in prison without the possibility of parole in the October 2017 attack. Jurors told the judge Monday that they were unable to reach the unanimous verdict required for a death sentence.The sentencing was the culmination of a trial that featured emotional testimony from survivors of the attack and relatives of the five tourists from Argentina, two Americans and a Belgian woman who were killed.The same jury convicted Saipov in January of 28 charges including murder in aid of racketeering and supporting a terrorist organization.It returned last month for a penalty phase to decide whether he should be sentenced to death or spend the rest of his life at a maximum ...

MPs want annual national-security reports, aid for businesses to thwart cyber threats

Published Wed, 27 Nov 2024 12:30:15 GMT

OTTAWA — A committee of MPs is calling on the federal government to issue an overarching annual national-security threat assessment and provide more information on how to prevent cyber attacks, particularly from Russia.“Concern about Russia is heightened because it has shown a willingness to cross internationally recognized red lines,” reads a report from the House of Commons committee on public safety.The report, tabled in Parliament last week, argues that the various agencies and committees handing national security issues operate in silos, and a patchwork of reports come from different sources.The MPs want someone in government to gather those recommendations and create an annual priority list. They say this should start with a review of the various “cyber roles, responsibilities, and structures that exist across the federal government” in order to “maximize coherence, co-ordination, and timely action.”The committee heard about malware and cybe...

Bears will sign LB Tremaine Edmunds, reports say

Published Wed, 27 Nov 2024 12:30:15 GMT

LAKE FOREST - For the first time as general manager of the Bears, Ryan Poles has gotten a big name player to agree to a major deal with the franchise.Per numerous reports, the first from Ian Rapoport of the NFL Network and Adam Schefter of ESPN, the Bears will sign former Bills inside linebacker Tremaine Edmunds to a four-year, $72 million deal that includes $50 million guaranteed.The team can confirm all new signings at the start of the new league year on Wednesday.A first round pick of Buffalo in 2018, Edmunds has played for the Bills during his first five seasons in the NFL and was named to the Pro Bowl in 2019 and 2020. In 15 games in 2022, the linebacker had 102 tackles with six for loss and a sack with an interception to go with seven passes defended. Bears trading No. 1 overall pick to Panthers, report says Edmunds was part of a Bills' team that has risen to one of the best in the NFL over his time in the league, including three-straight AFC East championships. This is the ...